MHF TOP PICKS FOR December
Every month, we at the Mueller Health Foundation like to showcase interesting news and updates in the field of tuberculosis. Below are our top 3 picks for December:
- Mini Bio-Devices Could Help TB Patients Stick to Their Treatments
Even after successful therapy for tuberculosis, survivors of the disease have an increased risk of recurrent infection and death. A study published by researchers at Baylor College of Medicine found that the cells of humans and animals who have recovered from tuberculosis had prematurely aged up to 12 to 14 years. To measure the aging of the cells, researchers looked at the epigenetic clock of the cells. Epigenetics looks at how the DNA inside every cell is coiled. As we age, how the DNA is coiled changes, and severe infection is changing it in such a way to increase premature aging. In this study, the researchers studied multiple cohorts and multiple tissue types, and discovered that tuberculosis induced perturbations in epigenetic regulation, specifically in the regulation mediated by DNA methylation. These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging. These processes were conserved across both guinea pigs and humans. To learn more, you can read the paper here: https://www.sciencedaily.com/releases/2022/03/220324130315.htm
- Study Finds that Tuberculosis Induces Premature Cellular Aging
Even after successful therapy for tuberculosis, survivors of the disease have an increased risk of recurrent infection and death. A study published by researchers at Baylor College of Medicine found that the cells of humans and animals who have recovered from tuberculosis had prematurely aged up to 12 to 14 years.
DID YOU KNOW?
The Center for Disease Control and Prevention (CDC) recently released a report titled “Reported Tuberculosis in the United States, 2021”. The report describes information on TB disease reported to the CDC since 1993, with an emphasis on TB disease cases counted by the reporting jurisdiction in 2021 and the ongoing effects of the COVID-19 pandemic on TB disease surveillance. Below is a summary of the key points from the report:
- The reported number of TB cases in the United States increased from 7,171 TB cases in 2020 to 7,882 TB cases in 2021, a 9.9% increase.
- The national TB incidence rate increased from 2.2 cases per 100,000 persons in 2020 to 2.4 cases per 100,000 persons in 2021. Nine states and the District of Columbia reported TB disease incidence rates higher than the national TB disease incidence rate.
- As in past years, cases of TB disease were not evenly distributed across the United States. Four states account for almost half (49.9%) of all reported US TB cases: California, Texas, New York (including New York City), and Florida.
- In 2021, people from racial and ethnic minority groups and non-US– born persons continued to be disproportionately affected by TB disease in the United States, highlighting the persistent health disparities and inequities among people with TB disease.