MHF TOP PICKS FOR November
Every month, we at the Mueller Health Foundation like to showcase interesting news and updates in the field of tuberculosis. Below are our top 3 picks for November:
- Tuberculosis and Diabetes Mellitus: Convergence of Two Epidemics
Diabetes mellitus prevalence is soaring globally, fuelled by obesity.
There is growing evidence that diabetes mellitus is an important risk
factor for tuberculosis and might affect disease presentation and
treatment response. Furthermore, tuberculosis might induce glucose
intolerance and worsen glycaemic control in people with diabetes.
The researches of this paper review the epidemiology of the
tuberculosis and diabetes epidemics, and provide a synopsis of the
evidence for the role of diabetes mellitus in susceptibility to, clinical
presentation of, and response to treatment for tuberculosis.
To learn more, you can access the full journal article at:
- The Interaction of Diabetes and Tuberculosis: Translating Research to Policy and Practice
Diabetes Mellitus increases the risk of developing Tuberculosis (TB) disease by about three times; it also doubles the risk of death during TB treatment and other poor TB treatment outcomes. Diabetes may increase the risk of latent infection with Mycobacterium tuberculosis (LTBI), but the magnitude of this effect is less clear. There are substantial research and policy gaps, particularly with regard to prevention of TB disease in people with diabetes and management of patients with TB–diabetes, both during TB treatment and after successful completion of TB treatment, when they likely remain at high risk of TB recurrence, mortality from TB and cardiovascular disease.
DID YOU KNOW?
This month, we would like to highlight some interesting facts related to Diabetes Mellitus (DM) and Tuberculosis (TB).
- Diabetes mellitus has affected approximately 425 million individuals in 2017 and is estimated to grow to 629 million people in 2045.
- More than 80% of type 2 diabetes mellitus, referred to colloquially as “diabetes”, is found in low- and middle-income countries and in areas where TB remains endemic.
- The risks of TB disease are significantly elevated in people with diabetes, about 2–3 times higher.
- Diabetes may also slightly increase the bacterial load of M tuberculosis and lengthen the time to smear or culture negativity; nearly twice as many patients with TB and diabetes remain culture positive at Months 2–3 compared to those with only TB.
- Many studies and reviews have now demonstrated that diabetes worsens TB treatment outcomes, in particular doubling the risk of death during TB treatment.
- Other studies have found that diabetes seems to increase the risk of TB recurrence and also appears to be associated with a doubling of the risk of identification of multidrug resistant TB.
Van Crevel, Reinout, and Julia A Critchley. “The Interaction of Diabetes and Tuberculosis: Translating Research to Policy and Practice.” Tropical medicine and infectious disease vol. 6,1 8. 8 Jan. 2021, doi:10.3390/tropicalmed6010008