Summary of Impact 2020

The Mueller Health Foundation

Investments Made

530,000 USD Distributed in Grant Funds in 2020

4,016,000 USD Committed through 2024

Investments Made by Strategic Pillar

$ 470,000 USD

Clinical Research and Precision Vaccine Development

$ 30,000 USD

Technology and TBConnect Blockchain Application Development

$ 30,000 USD

Educational Films and Advocacy Initiatives
Partnerships
Publications
handshake

8

New Partnerships

Established

paper

2

Press Releases

notepad

1

Scientific Paper

Publication

Education

1

Educational Video to

Increase Awareness for

TB

Pin copy

1

Infographic

Comparing TB and

COVID 19

Communication

2,900%

Increase in Twitter

Followers

3,800%

Increase in LinkedIn

Followers

>100

Average Views per Post on LinkedIn and Twitter

TBConnect Blockchain Application Platform Initiative
page fold

1

Application Development Roadmap

checkmarks

1

Complete Set of Specifications and User Stories

Laptop

>25

Wireframes Created

Cloud

3

Add-on features including blockchain smart-contracts capability, messaging, and teleconferencing

check

3

Phases of Application Development Completed

Skull

1

Iterative Testing Strategy and Developed and >120 Bugs Fixed

 Our Partners

InveniAI TBMeld AI-Platform Initiative

1. TB Prevention: Identification of Targets to Increase BCG Vaccine Efficacy
data structure copy1

18

Scientific Research Databases and Gene Databases scanned

folder file copy1

195,588

Scientific papers queried for identification of targets which can be combined with the TB BCG Vaccine to increase its efficacy

target copy1

98

Targets identified for potential combination with BCG to enhance efficacy of the BCG vaccine

66 Human

Targets

 


32 M.tb Targets


cpu copy1

75

Shortlisted targets ranked for Biological and Clinical relevance

hand pointer copy1

12

Top targets selected for Pathway-based Analysis

2. TB Treatment: Discovery of Novel and Alternative Treatment Combinations
data structurecopy

18

Scientific Research Databases and Gene Databases scanned

folder file copy

192,513

Scientific papers queried for identification of targets which can be combined with the TB BCG Vaccine to increase its efficacy

target copy

364

Relevant immune targets and pathways identified that can be further analyzed as new/alternative targets treatment combinations

231 Human Targets

133 M.tb
Targets

hand pointercopy

14

Top targets selected for Synergy Assessment through Framework-based analysis

Boston Children’s Hospital Precision Vaccine Program

people

3

New Hires, including 1 media relations expert and 2 laboratory members

people2

1

Planned, created, and convened working group of experts in vaccinology, immunology and infectious diseases to conduct landscape analysis of existing BCG vaccines

chemicals

 

Optimized antigen-specific in vitro readouts that will be used with fluorophore-conjugated Ag85b

microscope

Optimized flow cytometry panel to observe in vivo Th1/Th2/Th17 polarization

injection

100

BCG Denmark (SS I) vials sourced and en-route

+

20

BCG India vials in-house

hospital

1

Identified and evaluated participation in phase 2 clinical trial to assess G-Japan BCG in its ability to prevent viral respiratory infections, such as COVID-19

movie

1

Movie script for a 7-minute video to educate high-school students and above on tuberculosis

moviecut

19

Television interviews conducted by Ofer Levy, PhD